Global Youth Coalition on HIV/AIDS - Groups - Action Tools

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From:	Gabriel ADEYEMO [ profile ]
Subject:	Microbicides: Topical prevention against HIV
Sent:	Feb 8th, 2012 - 09:48:29

	AUTHORS: Shattock RJ, Rosenberg Z http://perspectivesinmedicine.cshlp.org/content/2/2/a007385.full Fellow Advocate and GYCAers, I believe this is all you need to know about Microbicides if you have not/have heard about it before. This is what most of us should be advocating for as it has been my main area of interest in this field of prevention science. * * * * Abstract Microbicides represent a potential intervention strategy for preventing HIV transmission. Vaginal microbicides would meet the need for a discreet method that women could use to protect themselves against HIV. Although early-generation microbicides failed to demonstrate efficacy, newer candidates are based on more potent antiretroviral (ARV) products. Positive data from the CAPRISA 004 trial of tenofovir gel support use in women and represent a turning point for the field. This article reviews current progress in development of ARV-based microbicides. We discuss the consensus on selection criteria, the potential for drug resistance, rationale for drug combinations, and the use of pharmacokinetic (PK)/pharmacodynamic (PD) assessment in product development. The urgent need for continued progress in development of formulations for sustained delivery is emphasized. Finally, as the boundaries between different prevention technologies become increasingly blurred, consideration is gi ven to the potential synergy of diverse approaches across the prevention landscape. More stories are available on the link above and i shall be grateful if you click on it and read more about Microbicides. -- Many Thanks Yours' in Prevention Science Gabriel, ADEYEMO Regional Focal Point - West Africa Global Youth Coalition on HIV/AID (GYCA) +234-80-6798-7317 \| gabriel (at) gyca.org www.gyca.org \| www.tigweb.org GYCA is a youth-led global network of over 6,000 young leaders and adult allies working on youth and HIV/AIDS in 173 countries world-wide. GYCA's mission is to empower young leaders with the skills, knowledge, resources and opportunities they need to scale up HIV/AIDS interventions amongst their peers. Universal Access is possible; * Zero new HIV infections. Zero discrimination and Zero AIDS-related deaths.*

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